Synthesis Of Novel 14 Substituted 12 - 1170 Words

Synthesis of novel 1,4-substituted 1,2,3-triazoles by water-soluble salen-Cu(II) catalyzed azide–alkyne cycloaddition in water Abstract A series of new 4-(1-azidoethyl)-1,1 -biphenyl derivatives were synthesized by the metal-free reductive reactions of biphenyl tosylhydrazones and sodium azide. The resulting biphenyl derivatives were further reacted with aryl acetylenes to afford novel 1,4-substituted 1,2,3-triazoles in 41–94% yield by water-soluble salen-Cu(II) catalyzed azide–alkyne cycloaddition in water in the absence of any organic solvent or phase transfer agent. Moreover, the catalytic system exhibited wide substrate scope and high functional-group tolerances. Introduction 1,2,3-Triazoles represent an important structural motif frequently found in organic chemistry [1], biological science [2], medicinal chemistry [3], and material science [4]. 1,2,3-triazoles and their derivatives have been extensively studied and have been proven of pharmacological importance owing to their heterocyclic core skeleton.[5] Thus, the synthesis of novel 1,2,3-triazoles derivatives by an efficient method has attracted considerable attention. Over the past few decades, the Cu(I)-catalyzed azide–alkyne cycloaddition reaction of organic azides as 1,3-dipoles and alkynes, also known as click chemistry, has become a useful and powerful tool for the facile formation of 1,2,3-triazoles with high yield, good regioselectivity, and high functional-group tolerances.[6–8] Accordingly, the design andShow MoreRelatedSynthesis Of Some Novel Pyrido Essay1556 Words   |  7 PagesSynthesis of some novel Pyrido [2, 3-d] pyrimidine derivatives as potential antimicrobial and an ticancer agents Mohamed Abd Ellatif Chemistry department, Faculty of science, Damanhour University, Egypt Email: mf_mohanad@yahoo.com mohamedabdellatif@dmu.edu.eg Abstract: The reactions of 2-amino-3-cyano-4.6-diarylpyridines with formic acid, glacial acetic acid, benzoyl chloride, formamide and acetamide afforded 5-(5-substitutedfuran-2-yl)-7-(4-substitutedphenyl)-3H-pyrido[2,3-d] Pyrimidin-4-oneRead MoreUltrasound Accelerated Syntheis of Novel Benzimidazole Derived Chalcones as ÃŽ ±-Glucosidases Inhibitor Agents2046 Words   |  8 PagesObjective: Present research work is carried out for rapid development of some biological active new heterocyclic moieties. Method: A novel series of 3-substituted-1-[1-(toluene-4-sulfonyl)-1H-benzoimidazol-2-yl]-propen-1-one (3a-3j) were synthesized by tosylation of benzimidazole chalcones (2a-2j) using ultrasound in lesser time with higher yields. All the synthesized compounds were characterized by Elemental analysis, IR spectra, 1H, 13C NMR and Mass spectroscopy. The newly synthesized compoundsRead MoreTb Is A Treatable And Curable Disease Essay1438 Words   |  6 Pagesin trial conditions. (5) However, this regimen also has unwanted aspects, which include the lengthy duration of the treatment, the side effects the drugs and, more concerning, the development of drug resistance, have significantly limited its use. (12) Furthermore, management of MDR-TB poses a bigger challenge, since resistance to isoniazid and rifampicin precludes the use of two key drugs in the anti-TB regimen. 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